loading...| Preferred Name |
Ras nucleotide exchange mediated by GRB2-SOS1 bound to FGFR mutants |
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| Synonyms |
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| Definitions |
Activation of Erk1/2 downstream of FGFR mutants suggests that, as is the case for WT FGFR, FGFR mutant-associated SOS1 activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state (see for instance, Weiss, 2010; Dutt, 2011; Raffioni, 1998; Cha, 2009; Hart, 2000; Turner, 2010; Kunii, 2008; Byron, 2008; Roidl, 2010; Chesi, 2001; Ronchetti, 2001; reviewed in Wesche, 2011). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008168 |
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| comment |
Activation of Erk1/2 downstream of FGFR mutants suggests that, as is the case for WT FGFR, FGFR mutant-associated SOS1 activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state (see for instance, Weiss, 2010; Dutt, 2011; Raffioni, 1998; Cha, 2009; Hart, 2000; Turner, 2010; Kunii, 2008; Byron, 2008; Roidl, 2010; Chesi, 2001; Ronchetti, 2001; reviewed in Wesche, 2011). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Pubmed11157491 Reactome, http://www.reactome.org Pubmed18757403 Pubmed19946327 Pubmed20179196 Pubmed21711248 Pubmed18381441 Pubmed21160078 Pubmed9857065 Pubmed21666749 Pubmed19103595 Pubmed11429702 |
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| label |
Ras nucleotide exchange mediated by GRB2-SOS1 bound to FGFR mutants |
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| prefixIRI |
HINO:0008168 |
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| prefLabel |
Ras nucleotide exchange mediated by GRB2-SOS1 bound to FGFR mutants |
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| seeAlso |
Reactome Database ID Release 431982085 ReactomeREACT_120761 |
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