loading...| Preferred Name |
Conversion of PIP2 to PIP3 by PI3K associated with FGFR mutants |
|
| Synonyms |
|
|
| Definitions |
Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0008161 |
|
| comment |
Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
|
| definition source |
Pubmed14534538 Pubmed17505008 Pubmed11739186 Reactome, http://www.reactome.org Pubmed15448205 Pubmed11689702 Pubmed18757403 Pubmed18381441 |
|
| has input | ||
| has output | ||
| label |
Conversion of PIP2 to PIP3 by PI3K associated with FGFR mutants |
|
| prefixIRI |
HINO:0008161 |
|
| prefLabel |
Conversion of PIP2 to PIP3 by PI3K associated with FGFR mutants |
|
| seeAlso |
Reactome Database ID Release 431986647 ReactomeREACT_121187 |
|
| subClassOf |