loading...| Preferred Name |
Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity |
|
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 10 FGFR4 N535K and FGFR4 V550E have been shown to undergo autophosphorylation when transfected into a murine rhabdomysarcoma (RMS) cell line and to promote transformation in NIH 3T3 cells. Receptor activation leads to increased signaling through STAT3, but decreased levels of phospho-AKT and phospho-Erk1/2 compared to vector control. Cells transfected with the N535K and V550E mutants also showed upregulation of cell cycle and DNA replication gene pathways and significantly higher growth rates (Taylor, 2009). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0008160 |
|
| comment |
has a Stoichiometric coefficient of 10 FGFR4 N535K and FGFR4 V550E have been shown to undergo autophosphorylation when transfected into a murine rhabdomysarcoma (RMS) cell line and to promote transformation in NIH 3T3 cells. Receptor activation leads to increased signaling through STAT3, but decreased levels of phospho-AKT and phospho-Erk1/2 compared to vector control. Cells transfected with the N535K and V550E mutants also showed upregulation of cell cycle and DNA replication gene pathways and significantly higher growth rates (Taylor, 2009). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
|
| definition source |
Reactome, http://www.reactome.org Pubmed19809159 |
|
| has input | ||
| has output | ||
| label |
Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity |
|
| prefixIRI |
HINO:0008160 |
|
| prefLabel |
Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity |
|
| seeAlso |
Reactome Database ID Release 432038944 ReactomeREACT_121260 EC Number: 2.7.10 |
|
| subClassOf |