loading...| Preferred Name |
Dimerization of FGFR1 point mutants with enhanced kinase activity |
|
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 2 Large scale genomic characterization of glioblastoma tumors has identified three point mutants in the kinase domain of FGFR1: N546K, R576W and K656E (Rand, 2005, TCGA, 2008), representing the first kinase domain point mutants identified in this gene in any cancer. These mutants are believed or have been shown to have enhanced kinase activity and to be able to function in a ligand-independent manner (Petiot, 2002; Lew, 2009; Raffioni, 1998, Rand, 2005; Hart, 2000) Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0008120 |
|
| comment |
has a Stoichiometric coefficient of 2 Large scale genomic characterization of glioblastoma tumors has identified three point mutants in the kinase domain of FGFR1: N546K, R576W and K656E (Rand, 2005, TCGA, 2008), representing the first kinase domain point mutants identified in this gene in any cancer. These mutants are believed or have been shown to have enhanced kinase activity and to be able to function in a ligand-independent manner (Petiot, 2002; Lew, 2009; Raffioni, 1998, Rand, 2005; Hart, 2000) Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
|
| definition source |
Pubmed18772890 Reactome, http://www.reactome.org Pubmed19224897 Pubmed12112473 Pubmed16186508 Pubmed10918587 Pubmed9857065 |
|
| has input | ||
| has output | ||
| label |
Dimerization of FGFR1 point mutants with enhanced kinase activity |
|
| prefixIRI |
HINO:0008120 |
|
| prefLabel |
Dimerization of FGFR1 point mutants with enhanced kinase activity |
|
| seeAlso |
Reactome Database ID Release 432023456 ReactomeREACT_120981 |
|
| subClassOf |