loading...| Preferred Name |
Phosphorylation of STAT5 by FGFR1 fusions |
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| Synonyms |
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| Definitions |
Activation of a subset of FGFR1-fusions (ZMYM2, BCR, FGFR1OP2 and CUX) has been shown to result in downstream phosphorylation of STAT5 proteins at Y694. This phosphorylation is dependent on the FGFR1 fusion, as the STAT5 phosphorylation is abrogated in the presence of an FGFR1-kinase dead fusion (Heath and Cross, 2004; Smedley, 1999; Chase, 2007; Wasage, 2011). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008116 |
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| comment |
Activation of a subset of FGFR1-fusions (ZMYM2, BCR, FGFR1OP2 and CUX) has been shown to result in downstream phosphorylation of STAT5 proteins at Y694. This phosphorylation is dependent on the FGFR1 fusion, as the STAT5 phosphorylation is abrogated in the presence of an FGFR1-kinase dead fusion (Heath and Cross, 2004; Smedley, 1999; Chase, 2007; Wasage, 2011). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Pubmed17698633 Pubmed21330321 Reactome, http://www.reactome.org Pubmed10935490 Pubmed14660670 |
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| label |
Phosphorylation of STAT5 by FGFR1 fusions |
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| prefixIRI |
HINO:0008116 |
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| prefLabel |
Phosphorylation of STAT5 by FGFR1 fusions |
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| seeAlso |
Reactome Database ID Release 431839112 ReactomeREACT_121048 EC Number: 2.7.10 |
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