Preferred Name |
FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 |
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Synonyms |
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Definitions |
Expression of FGFR1OP-FGFR1 in both Ba/F3 and Cos-1 cells leads to phosphorylation of STAT1 and STAT3 but not STAT5, and to activation of a STAT1/3-responsive reporter when expressed in NIH3T3 cells (Guasch, 2001). Activation of STAT proteins has also been shown to be oncogenic in the context of derivatives of FGFR1, 3 and 4 that lack the extracellular domain and are are targetted to the plasma membrane by a myristylation signal (Hart et al, 2000). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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ID |
http://purl.obolibrary.org/obo/HINO_0008115 |
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comment |
Expression of FGFR1OP-FGFR1 in both Ba/F3 and Cos-1 cells leads to phosphorylation of STAT1 and STAT3 but not STAT5, and to activation of a STAT1/3-responsive reporter when expressed in NIH3T3 cells (Guasch, 2001). Activation of STAT proteins has also been shown to be oncogenic in the context of derivatives of FGFR1, 3 and 4 that lack the extracellular domain and are are targetted to the plasma membrane by a myristylation signal (Hart et al, 2000). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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definition source |
Reactome, http://www.reactome.org Pubmed11689702 Pubmed10918587 |
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has output | ||
label |
FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 |
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prefixIRI |
HINO:0008115 |
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prefLabel |
FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 |
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seeAlso |
EC Number: 2.7.10 ReactomeREACT_121233 Reactome Database ID Release 431888198 |
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subClassOf |