loading...| Preferred Name |
Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions |
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| Synonyms |
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| Definitions |
Activation of the PI3K pathway has been demonstrated in the case of ZMYM2-FGFR1 (Chen, 2004), BCR-FGFR1 (Demiroglu, 2001) and FOP-FGFR1 (Guasch, 2001), and is presumed to occur to a greater or lesser extent in other FGFR1 fusions as well (reviewed in Jackson, 2010). Activation of the PI3K pathway suggests that the PIK3CA catalytic subunit must be recruited to the fusion protein. Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008114 |
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| comment |
Activation of the PI3K pathway has been demonstrated in the case of ZMYM2-FGFR1 (Chen, 2004), BCR-FGFR1 (Demiroglu, 2001) and FOP-FGFR1 (Guasch, 2001), and is presumed to occur to a greater or lesser extent in other FGFR1 fusions as well (reviewed in Jackson, 2010). Activation of the PI3K pathway suggests that the PIK3CA catalytic subunit must be recruited to the fusion protein. Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Pubmed20226962 Pubmed11739186 Reactome, http://www.reactome.org Pubmed15448205 Pubmed11689702 |
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| label |
Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions |
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| prefixIRI |
HINO:0008114 |
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| prefLabel |
Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions |
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| seeAlso |
Reactome Database ID Release 431839080 ReactomeREACT_121216 |
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