loading...| Preferred Name |
Autocatalytic phosphorylation of FGFR4 Y367C mutant |
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| Synonyms |
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| Definitions |
Expression of the FGFR4 Y367C mutant in MDA-MB453 breast cancer cell line results in constitutive tyrosine phosphorylation of the receptor and serum-independent activation of downstream signaling as monitored by Erk phosphorylation. Ectopic expression of FGFR4 Y367C in HEK cells also leads to Erk activation and enhanced cellular proliferation. Akt and phospho-AKT levels were not affected by overexpression of the FGFR4 Y367C mutant, however (Roidl, 2010) has a Stoichiometric coefficient of 10 Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008109 |
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| comment |
Expression of the FGFR4 Y367C mutant in MDA-MB453 breast cancer cell line results in constitutive tyrosine phosphorylation of the receptor and serum-independent activation of downstream signaling as monitored by Erk phosphorylation. Ectopic expression of FGFR4 Y367C in HEK cells also leads to Erk activation and enhanced cellular proliferation. Akt and phospho-AKT levels were not affected by overexpression of the FGFR4 Y367C mutant, however (Roidl, 2010) has a Stoichiometric coefficient of 10 Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Reactome, http://www.reactome.org Pubmed19946327 |
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| label |
Autocatalytic phosphorylation of FGFR4 Y367C mutant |
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| prefixIRI |
HINO:0008109 |
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| prefLabel |
Autocatalytic phosphorylation of FGFR4 Y367C mutant |
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| seeAlso |
ReactomeREACT_121299 EC Number: 2.7.10 Reactome Database ID Release 432012087 |
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