loading...| Preferred Name |
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors |
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| Definitions |
has a Stoichiometric coefficient of 2 FGFR3 has been shown to be a target of a range of different tyrosine kinase inhibitors, including those restricted to in vitro use as well as a number that are currently in clinical trials for therapeutic use (see for instance, Paterson, 2004; Trudel, 2004; Trudel, 2005; Grand, 2004, Chen, 2005; Bernard-Pierrot, 2006; http::/clinicaltrials.gov). There are also two anti-FGFR3 antibodies that have shown preliminary promise in cancer cell lines or mouse models (Qing, 2009; Trudel, 2006). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008106 |
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| comment |
has a Stoichiometric coefficient of 2 FGFR3 has been shown to be a target of a range of different tyrosine kinase inhibitors, including those restricted to in vitro use as well as a number that are currently in clinical trials for therapeutic use (see for instance, Paterson, 2004; Trudel, 2004; Trudel, 2005; Grand, 2004, Chen, 2005; Bernard-Pierrot, 2006; http::/clinicaltrials.gov). There are also two anti-FGFR3 antibodies that have shown preliminary promise in cancer cell lines or mouse models (Qing, 2009; Trudel, 2006). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Pubmed16091734 Pubmed14715624 Pubmed18757432 Pubmed19381019 Reactome, http://www.reactome.org Pubmed15029211 Pubmed15598814 Pubmed16467200 Pubmed14871245 |
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| label |
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors |
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| prefixIRI |
HINO:0008106 |
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| prefLabel |
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors |
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| seeAlso |
ReactomeREACT_121067 Reactome Database ID Release 432077420 |
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