loading...| Preferred Name |
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding |
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| Synonyms |
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| Definitions |
has a Stoichiometric coefficient of 16 After aberrantly dimerizing in response to mesenchymally expressed ligands, FGFR2c S252W and P253R mutants are assumed to undergo transautophosphorylation analagous to the wild-type receptor, although this has not been explicitly demonstrated. Knock-down or chemical inhibition of other FGFR2-activating mutations identified in endometrial cancer cells has been shown to cause cell death (Byron, 2008). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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http://purl.obolibrary.org/obo/HINO_0008091 |
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| comment |
has a Stoichiometric coefficient of 16 After aberrantly dimerizing in response to mesenchymally expressed ligands, FGFR2c S252W and P253R mutants are assumed to undergo transautophosphorylation analagous to the wild-type receptor, although this has not been explicitly demonstrated. Knock-down or chemical inhibition of other FGFR2-activating mutations identified in endometrial cancer cells has been shown to cause cell death (Byron, 2008). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Reactome, http://www.reactome.org Pubmed18757403 |
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| label |
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding |
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| prefixIRI |
HINO:0008091 |
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| prefLabel |
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding |
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| seeAlso |
ReactomeREACT_121004 EC Number: 2.7.10 Reactome Database ID Release 432033486 |
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