loading...| Preferred Name | Negative regulation of RIG-I/MDA5 signaling by TRIAD3A | |
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| Definitions |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-22 TRAF3 is dual regulated by DUBA and TRIAD3A. TRAF3 K63-polyubiquitin is removed by DUBA to disrupt TRAF3-TBK1/IKKi interactions. TRAF3 then undergoes a late phase K48-linked polyubiquitination by TRIAD3A, leading to TRAF3 proteasomal degradation. Thus TRIAD3A acts as a E3- ubiquitin ligase that negatively regulates RLR pathway. |
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http://purl.obolibrary.org/obo/HINO_0008087 |
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| comment |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-22 TRAF3 is dual regulated by DUBA and TRIAD3A. TRAF3 K63-polyubiquitin is removed by DUBA to disrupt TRAF3-TBK1/IKKi interactions. TRAF3 then undergoes a late phase K48-linked polyubiquitination by TRIAD3A, leading to TRAF3 proteasomal degradation. Thus TRIAD3A acts as a E3- ubiquitin ligase that negatively regulates RLR pathway. |
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| definition source |
Reactome, http://www.reactome.org Pubmed19893624 |
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Negative regulation of RIG-I/MDA5 signaling by TRIAD3A |
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HINO:0008087 |
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Negative regulation of RIG-I/MDA5 signaling by TRIAD3A |
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| seeAlso |
ReactomeREACT_24974 Reactome Database ID Release 43936475 |
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