loading...| Preferred Name | Pre-pro-defensins are cleaved to remove the signal peptide | |
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| Definitions |
Authored: Jupe, S, 2011-04-28 Reviewed: McDermott, AM, 2011-11-03 Edited: Jupe, S, 2011-07-27 Pre-pro-defensins are cleaved in the golgi by undefined proteases which remove the signal peptide (Yang et al. 2004, Pazgier et al. 2006). Subsequently, alpha-defensins are cleaved again to produce the biologically active mature peptide. Beta defensins have much shorter propieces and may be active once the signal peptide is removed. Further N-terminal processing of the mature defensin may yield multiple forms of the same peptide (Pazgier et al. 2006). |
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http://purl.obolibrary.org/obo/HINO_0008072 |
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| comment |
Authored: Jupe, S, 2011-04-28 Reviewed: McDermott, AM, 2011-11-03 Edited: Jupe, S, 2011-07-27 Pre-pro-defensins are cleaved in the golgi by undefined proteases which remove the signal peptide (Yang et al. 2004, Pazgier et al. 2006). Subsequently, alpha-defensins are cleaved again to produce the biologically active mature peptide. Beta defensins have much shorter propieces and may be active once the signal peptide is removed. Further N-terminal processing of the mature defensin may yield multiple forms of the same peptide (Pazgier et al. 2006). |
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| definition source |
Reactome, http://www.reactome.org Pubmed12949495 Pubmed16710608 Pubmed15032578 |
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| label |
Pre-pro-defensins are cleaved to remove the signal peptide |
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| prefixIRI |
HINO:0008072 |
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| prefLabel |
Pre-pro-defensins are cleaved to remove the signal peptide |
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| seeAlso |
ReactomeREACT_115619 Reactome Database ID Release 431462023 |
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