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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Recruitment of AIP4 and K-48 ubiquitination of MAVS/IPS-1 | |
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| Definitions |
Reviewed: Kawai, T, Akira, S, 2010-10-30 On viral infection PCB2 binds MAVS/IPS-1 and recruits the HECT domain-containing E3 ligase AIP4/ITCHY. AIP4 catalyses K48-polyubiquitination and degradation of MAVS. PCBP2 overexpression enhanced the interaction between MAVS and AIP4 and led to more degradation of MAVS. MAVS/IPS-1 regulation is very important in preventing excessive harmful immune responses. Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008070 |
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| comment |
Reviewed: Kawai, T, Akira, S, 2010-10-30 On viral infection PCB2 binds MAVS/IPS-1 and recruits the HECT domain-containing E3 ligase AIP4/ITCHY. AIP4 catalyses K48-polyubiquitination and degradation of MAVS. PCBP2 overexpression enhanced the interaction between MAVS and AIP4 and led to more degradation of MAVS. MAVS/IPS-1 regulation is very important in preventing excessive harmful immune responses. Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02
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| definition source |
Reactome, http://www.reactome.org Pubmed19881509
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| has input |
http://purl.obolibrary.org/obo/UniProt_Q96J02 |
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| has output | ||
| label |
Recruitment of AIP4 and K-48 ubiquitination of MAVS/IPS-1
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| prefixIRI |
HINO:0008070
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| prefLabel |
Recruitment of AIP4 and K-48 ubiquitination of MAVS/IPS-1
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| seeAlso |
Reactome Database ID Release 43990526 EC Number: 6.3.2.19 ReactomeREACT_25398
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