loading...| Preferred Name | Alpha-defensins form biologically active dimers | |
| Synonyms |
|
|
| Definitions |
Authored: Jupe, S, 2011-04-28 has a Stoichiometric coefficient of 2 Reviewed: McDermott, AM, 2011-11-03 Edited: Jupe, S, 2011-07-27 The crystal structure of human alpha-defensin HNP-3 revealed that it forms a dimer containing a six-stranded beta-sheet region (Hill et al. 1991). NMR studies indicate that HNP-1 can also form dimers or higher-order aggregates in solution and artificial lipid bilayers (Zhang et al. 1992, 2010a, 2010b). Models of alpha and beta defensins suggest that dimerization and/or higher order structures are characteristic, though not univeral or required for the biological effects of some beta-defensins (Suresh & Verma 2006, Pazgier et al. 2006). |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0008056 |
|
| comment |
Authored: Jupe, S, 2011-04-28 has a Stoichiometric coefficient of 2 Reviewed: McDermott, AM, 2011-11-03 Edited: Jupe, S, 2011-07-27 The crystal structure of human alpha-defensin HNP-3 revealed that it forms a dimer containing a six-stranded beta-sheet region (Hill et al. 1991). NMR studies indicate that HNP-1 can also form dimers or higher-order aggregates in solution and artificial lipid bilayers (Zhang et al. 1992, 2010a, 2010b). Models of alpha and beta defensins suggest that dimerization and/or higher order structures are characteristic, though not univeral or required for the biological effects of some beta-defensins (Suresh & Verma 2006, Pazgier et al. 2006). |
|
| definition source |
Pubmed17088326 Pubmed20097206 Reactome, http://www.reactome.org Pubmed20961099 Pubmed2006422 Pubmed1445872 Pubmed17254301 |
|
| has input | ||
| has output | ||
| label |
Alpha-defensins form biologically active dimers |
|
| prefixIRI |
HINO:0008056 |
|
| prefLabel |
Alpha-defensins form biologically active dimers |
|
| seeAlso |
ReactomeREACT_115822 Reactome Database ID Release 431462014 |
|
| subClassOf |