loading...| Preferred Name | DAI binds cytosolic DNA | |
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| Definitions |
has a Stoichiometric coefficient of 2 Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- DAI binds to double-stranded DNA in vitro and in vivo (Wang ZC et al 2008; Takaoka A et al 2007). N-teminus of DAI contains two Z-DNA (Zalpha and Zbeta) and one B-DNA binding domains (D3 region). D3 region mediates initial binding of DAI to DNA with subsequent stabilization provided by the Zalpha and Zbeta domains. All tree DNA-binding domains are required for DAI full activation (Wang ZC et al 2008). <p>DAI was reported to form multimer upon DNA binding that might facilitate innate immune responces (Wang ZC et al 2008; Ha SC et al 2008). Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21 |
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http://purl.obolibrary.org/obo/HINO_0008034 |
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has a Stoichiometric coefficient of 2 Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- DAI binds to double-stranded DNA in vitro and in vivo (Wang ZC et al 2008; Takaoka A et al 2007). N-teminus of DAI contains two Z-DNA (Zalpha and Zbeta) and one B-DNA binding domains (D3 region). D3 region mediates initial binding of DAI to DNA with subsequent stabilization provided by the Zalpha and Zbeta domains. All tree DNA-binding domains are required for DAI full activation (Wang ZC et al 2008). DAI was reported to form multimer upon DNA binding that might facilitate innate immune responces (Wang ZC et al 2008; Ha SC et al 2008). Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21 |
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| definition source |
Pubmed18375758 Pubmed21471454 Reactome, http://www.reactome.org Pubmed17618271 Pubmed19095800 |
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DAI binds cytosolic DNA |
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| prefixIRI |
HINO:0008034 |
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| prefLabel |
DAI binds cytosolic DNA |
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Reactome Database ID Release 431591234 ReactomeREACT_118621 |
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