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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Recruitment TBK1 to dsDNA:DAI followed by its activation | |
| Synonyms |
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| Definitions |
has a Stoichiometric coefficient of 2 DAI dimer formation enables recruitment of TBK1 and IRF3 to the C-terminal region of DAI in response to cytosolic DNA in murine L929 cells. This interaction is DNA-dependent as DAI mutants that lack DNA binding domains neither recruited TBK1 nor activated IRF3 (Takaoka A et al 2007). Activation of IRF-3 and possibly IRF-7 promotes IFN gene expression. Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008033 |
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| comment |
has a Stoichiometric coefficient of 2 DAI dimer formation enables recruitment of TBK1 and IRF3 to the C-terminal region of DAI in response to cytosolic DNA in murine L929 cells. This interaction is DNA-dependent as DAI mutants that lack DNA binding domains neither recruited TBK1 nor activated IRF3 (Takaoka A et al 2007). Activation of IRF-3 and possibly IRF-7 promotes IFN gene expression. Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21
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| definition source |
Reactome, http://www.reactome.org Pubmed17618271
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| has input |
http://purl.obolibrary.org/obo/UniProt_Q9UHD2 |
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| has output | ||
| label |
Recruitment TBK1 to dsDNA:DAI followed by its activation
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| prefixIRI |
HINO:0008033
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| prefLabel |
Recruitment TBK1 to dsDNA:DAI followed by its activation
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| seeAlso |
ReactomeREACT_118783 Reactome Database ID Release 431606324
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| subClassOf |
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