Human Interaction Network Ontology

Last uploaded: June 27, 2014
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Id http://purl.obolibrary.org/obo/HINO_0007995
http://purl.obolibrary.org/obo/HINO_0007995
Preferred Name

DAI recruits RIP1 and RIP3
Definitions
Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- Edited: Shamovsky, V, 2012-02-23 Two RIP homotypic interaction motifs (RHIM) were identified in the DAI protein sequence. These two domains were shown to be essential for DAI-induced NFkB activation in human embryonic kidney 293T (HEK293T) cells. DAI forms a complex with two RHIM-containing kinases - RIP1 and RIP3 (Kaiser WJ et al 2008, Rebsamen M et al 2009). Recruitment of RIP3 to DAI was reported to induce RIP3 autophosphorylation. Furthermore, knockdown of RIP1 or RIP3 affected DAI-induced NFkB signals in murine L929 fibroblast and human HEK293T cells (Kaiser WJ et al 2008, Rebsamen M et al 2009). Authored: Shamovsky, V, 2011-09-21
Type http://www.w3.org/2002/07/owl#Class

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label
DAI recruits RIP1 and RIP3
comment
Reviewed: D'Eustachio, P, 2011-12-07
Reviewed: Upton, JW, Mocarski, ES, 2012--0-2-
Edited: Shamovsky, V, 2012-02-23
Two RIP homotypic interaction motifs (RHIM) were identified in the DAI protein sequence. These two domains were shown to be essential for DAI-induced NFkB activation in human embryonic kidney 293T (HEK293T) cells. DAI forms a complex with two RHIM-containing kinases - RIP1 and RIP3 (Kaiser WJ et al 2008, Rebsamen M et al 2009). Recruitment of RIP3 to DAI was reported to induce RIP3 autophosphorylation. Furthermore, knockdown of RIP1 or RIP3 affected DAI-induced NFkB signals in murine L929 fibroblast and human HEK293T cells (Kaiser WJ et al 2008, Rebsamen M et al 2009).
Authored: Shamovsky, V, 2011-09-21
prefLabel
DAI recruits RIP1 and RIP3
definition source
Reactome, http://www.reactome.org
Pubmed19590578
Pubmed18941233
prefixIRI
HINO:0007995
seeAlso
ReactomeREACT_118851
Reactome Database ID Release 431810457
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