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Human Interaction Network Ontology
| Preferred Name | Phosphorylation and release of IRF3 | |
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| Definitions |
has a Stoichiometric coefficient of 2 Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- IRF3 is activated through a two-step phosphorylation in the C-terminal domain mediated by TBK1 and/or IKKi, requiring Ser386 and/or Ser385- site 1; and a cluster of serine/threonine residues between Ser396 and Ser405- site 2 [Panne et al 2007]. Phosphorylated residues at site 2 (Ser396 - Ser405) alleviate autoinhibition to allow interaction with CBP (CREB-binding protein) and facilitate phosphorylation at site 1 (Ser385 or Ser386). Phosphorylation at site 1 is required for IRF3 dimerization. has a Stoichiometric coefficient of 10 Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007993 |
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| comment |
has a Stoichiometric coefficient of 2 Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- IRF3 is activated through a two-step phosphorylation in the C-terminal domain mediated by TBK1 and/or IKKi, requiring Ser386 and/or Ser385- site 1; and a cluster of serine/threonine residues between Ser396 and Ser405- site 2 [Panne et al 2007]. Phosphorylated residues at site 2 (Ser396 - Ser405) alleviate autoinhibition to allow interaction with CBP (CREB-binding protein) and facilitate phosphorylation at site 1 (Ser385 or Ser386). Phosphorylation at site 1 is required for IRF3 dimerization. has a Stoichiometric coefficient of 10 Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21
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| definition source |
Pubmed9463386 Pubmed12692549 Reactome, http://www.reactome.org Pubmed17526488
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| has input | ||
| has output |
http://purl.obolibrary.org/obo/HINO_0003129 |
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| label |
Phosphorylation and release of IRF3
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| prefixIRI |
HINO:0007993
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| prefLabel |
Phosphorylation and release of IRF3
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| seeAlso |
ReactomeREACT_118685 Reactome Database ID Release 431606327
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