loading...| Preferred Name | RIG-I/MDA5 interacts with IPS-1 | |
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| Definitions |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Upon binding the dsRNA, RIG-I and MDA5 recruit downstream signal transducer, a mitochondria-bound protein: IPS-1/VISA/MAVS/CARDIF. This mitochondria-bound adaptor has been given four different names according to the various groups who identified it: MAVS, mitochondrial antiviral signaling; IPS-1, interferonbeta promoter stimulator 1; VISA, virus-induced signaling adaptor; CARDIF, CARD adaptor inducing IFNbeta. IPS-1 is an adaptor protein with an N-terminal CARD-like domain (CLD) and with this it associates with the CARD regions of RIG-I and MDA5 and mediate the induction of interferons. Authored: Garapati, P V, 2010-08-02 |
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http://purl.obolibrary.org/obo/HINO_0007963 |
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| comment |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Upon binding the dsRNA, RIG-I and MDA5 recruit downstream signal transducer, a mitochondria-bound protein: IPS-1/VISA/MAVS/CARDIF. This mitochondria-bound adaptor has been given four different names according to the various groups who identified it: MAVS, mitochondrial antiviral signaling; IPS-1, interferonbeta promoter stimulator 1; VISA, virus-induced signaling adaptor; CARDIF, CARD adaptor inducing IFNbeta. IPS-1 is an adaptor protein with an N-terminal CARD-like domain (CLD) and with this it associates with the CARD regions of RIG-I and MDA5 and mediate the induction of interferons. Authored: Garapati, P V, 2010-08-02 |
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| definition source |
Pubmed16153868 Pubmed16127453 Reactome, http://www.reactome.org Pubmed16125763 Pubmed18307765 |
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RIG-I/MDA5 interacts with IPS-1 |
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HINO:0007963 |
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| prefLabel |
RIG-I/MDA5 interacts with IPS-1 |
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| seeAlso |
Reactome Database ID Release 43168909 ReactomeREACT_24957 |
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