Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Caspase-8 (casp-8) and caspase-10 (casp-10) are involved in RIG-I/MDA5-dependent antiviral immune responses. Caspase-8/10 activation contributes to NF-kB activation in response to viral dsRNA.<br>Caspase-8/10 are synthesized as zymogens (procaspases), containing a large N-terminal prodomain with two death effector domains (DED), and a C-terminal catalytic subunit composed of small and a large domain separated by a smaller linker region. FADD plays a crucial role in the recruitment and activation of procaspase-8/10. The two DED domains of procaspase-8/10 interacts with DED domain of FADD. Authored: Garapati, P V, 2010-08-02

http://purl.obolibrary.org/obo/HINO_0007943

Reviewed: Kawai, T, Akira, S, 2010-10-30

Edited: Garapati, P V, 2010-08-02

Caspase-8 (casp-8) and caspase-10 (casp-10) are involved in RIG-I/MDA5-dependent antiviral immune responses. Caspase-8/10 activation contributes to NF-kB activation in response to viral dsRNA.
Caspase-8/10 are synthesized as zymogens (procaspases), containing a large N-terminal prodomain with two death effector domains (DED), and a C-terminal catalytic subunit composed of small and a large domain separated by a smaller linker region. FADD plays a crucial role in the recruitment and activation of procaspase-8/10. The two DED domains of procaspase-8/10 interacts with DED domain of FADD.

Authored: Garapati, P V, 2010-08-02

Pubmed12884866

Reactome, http://www.reactome.org

Pubmed18761323

Pubmed12107169

Pubmed16585540

Pubmed11717445

Pubmed16618810

http://purl.obolibrary.org/obo/HINO_0003469

http://purl.obolibrary.org/obo/HINO_0006184

http://purl.obolibrary.org/obo/HINO_0003449

Recruitment of caspase-8 and -10 to FADD complex

HINO:0007943

Recruitment of caspase-8 and -10 to FADD complex

Reactome Database ID Release 43933526

ReactomeREACT_25167

http://purl.obolibrary.org/obo/INO_0000040