loading...| Preferred Name | RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 | |
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Reviewed: Kawai, T, Akira, S, 2010-10-30 RNF125 acts as an E3-ubiquitin ligase that conjugates with RIG-I, MDA5 and IPS-1 and mediate their proteosomal degradation. UbcH1, UbcH5a, UbcH5b, and UbcH5c function as an E2 enzyme and conjugate ubiquitin to RNF125 and RIG-1 via K48. Among these enzymes UbcH5c is the major E2 enzyme showing enhanced ubiquitin conjugation to RIG-I. RNF125 mediated ubiquitination of RIG-I/MDA5 and IPS1 inhibits RIG-I signaling by shunting these proteins toward proteasomal degradation. Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-22 |
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http://purl.obolibrary.org/obo/HINO_0007923 |
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Reviewed: Kawai, T, Akira, S, 2010-10-30 RNF125 acts as an E3-ubiquitin ligase that conjugates with RIG-I, MDA5 and IPS-1 and mediate their proteosomal degradation. UbcH1, UbcH5a, UbcH5b, and UbcH5c function as an E2 enzyme and conjugate ubiquitin to RNF125 and RIG-1 via K48. Among these enzymes UbcH5c is the major E2 enzyme showing enhanced ubiquitin conjugation to RIG-I. RNF125 mediated ubiquitination of RIG-I/MDA5 and IPS1 inhibits RIG-I signaling by shunting these proteins toward proteasomal degradation. Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-22 |
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Pubmed18703349 Pubmed17460044 Reactome, http://www.reactome.org |
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http://purl.obolibrary.org/obo/HINO_0006161 |
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RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 |
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HINO:0007923 |
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RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 |
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ReactomeREACT_25252 EC Number: 6.3.2.19 Reactome Database ID Release 43936412 |
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