loading...| Preferred Name | Inhibition of RIG-I/MDA5 signaling by ATG5-ATG12 conjugate | |
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Reviewed: Kawai, T, Akira, S, 2010-10-30 Autophagy protein 5 (ATG5) and autophagy-related protein 12 (ATG12) conjugate negatively regulates the type I IFN production pathway by directly associating with RIG-I/MDA5 and IPS-1 through the caspase recruitment domains (CARDs). The ATG5-ATG12 conjugate intercalates between the CARDs of RIG-I/MDA5 and IPS-1 and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses. Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 |
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http://purl.obolibrary.org/obo/HINO_0007912 |
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Reviewed: Kawai, T, Akira, S, 2010-10-30 Autophagy protein 5 (ATG5) and autophagy-related protein 12 (ATG12) conjugate negatively regulates the type I IFN production pathway by directly associating with RIG-I/MDA5 and IPS-1 through the caspase recruitment domains (CARDs). The ATG5-ATG12 conjugate intercalates between the CARDs of RIG-I/MDA5 and IPS-1 and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses. Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 |
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| definition source |
Reactome, http://www.reactome.org Pubmed17709747 |
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Inhibition of RIG-I/MDA5 signaling by ATG5-ATG12 conjugate |
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HINO:0007912 |
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Inhibition of RIG-I/MDA5 signaling by ATG5-ATG12 conjugate |
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Reactome Database ID Release 43936378 ReactomeREACT_24982 |
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