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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | PIN1 mediated IRF3 degradation | |
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| Definitions |
Reviewed: Kawai, T, Akira, S, 2010-10-30 PIN1 acts as a negative regulator of IFN induction. Its association with IRF3 leads to ubiquitin-mediated proteosomal degradation of IRF3. PIN1 on its own does not have ubiquitin activation, transfer or ligase activities. Exactly how this IRF3 degradation is achieved is unclear at present. Immunoprecipitation of ubiquitin followed by immunoblot analysis for IRF3 demonstrated that polyubiquitination of IRF3 was induced by RNA stimulation and that polyubiquitination was augmented by PIN1 expression and abrogated by expression of PIN1-specific shRNA. Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-22 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007906 |
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Reviewed: Kawai, T, Akira, S, 2010-10-30 PIN1 acts as a negative regulator of IFN induction. Its association with IRF3 leads to ubiquitin-mediated proteosomal degradation of IRF3. PIN1 on its own does not have ubiquitin activation, transfer or ligase activities. Exactly how this IRF3 degradation is achieved is unclear at present. Immunoprecipitation of ubiquitin followed by immunoblot analysis for IRF3 demonstrated that polyubiquitination of IRF3 was induced by RNA stimulation and that polyubiquitination was augmented by PIN1 expression and abrogated by expression of PIN1-specific shRNA. Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-22
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| definition source |
Pubmed16715065 Reactome, http://www.reactome.org Pubmed19125153 Pubmed16699525
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PIN1 mediated IRF3 degradation
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HINO:0007906
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PIN1 mediated IRF3 degradation
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EC Number: 6.3.2.19 Reactome Database ID Release 43936462 ReactomeREACT_24932
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