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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Activation of STAT5a/b by JAK2 | |
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| Definitions |
Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 JAK2 phosphorylates STAT5; phosphorylated STAT5 dimerizes and translocates to the nucleus (Darnell et al., 1994), binds DNA and activates target genes including c-fos, pim-1, oncostatin M, and Id-1 (Mui et al. 1996). STAT5 activation is believed to be the primary signaling mechanism for Bc (Ihle, 2001). Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06 has a Stoichiometric coefficient of 6 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007483 |
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| comment |
Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 JAK2 phosphorylates STAT5; phosphorylated STAT5 dimerizes and translocates to the nucleus (Darnell et al., 1994), binds DNA and activates target genes including c-fos, pim-1, oncostatin M, and Id-1 (Mui et al. 1996). STAT5 activation is believed to be the primary signaling mechanism for Bc (Ihle, 2001). Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06 has a Stoichiometric coefficient of 6
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| definition source |
Pubmed8665850 Reactome, http://www.reactome.org Pubmed9685210 Pubmed11458499 Pubmed8197455
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Activation of STAT5a/b by JAK2
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| prefixIRI |
HINO:0007483
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| prefLabel |
Activation of STAT5a/b by JAK2
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| seeAlso |
ReactomeREACT_23842 EC Number: 2.7.10 Reactome Database ID Release 43879909
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