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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0007475
http://purl.obolibrary.org/obo/HINO_0007475
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|---|---|
| Preferred Name | Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 |
| Definitions |
Authored: Ray, KP, 2010-05-17
Edited: Jupe, S, 2010-08-06
The alpha subunit of the IL3 receptor binds IL 3 with low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008). Covalent linkage of the receptor subunits is required for receptor signalling (Stomski et al. 1996).
Reviewed: Lopez, AF, 2010-09-06
Reviewed: Hercus, TR, 2010-09-06
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
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| comment |
Authored: Ray, KP, 2010-05-17
Edited: Jupe, S, 2010-08-06
The alpha subunit of the IL3 receptor binds IL 3 with low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008). Covalent linkage of the receptor subunits is required for receptor signalling (Stomski et al. 1996).
Reviewed: Lopez, AF, 2010-09-06
Reviewed: Hercus, TR, 2010-09-06
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| prefLabel |
Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
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| definition source |
Pubmed8649415
Pubmed1833064
Reactome, http://www.reactome.org
Pubmed18692472
Pubmed10477686
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| prefixIRI |
HINO:0007475
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| seeAlso |
Reactome Database ID Release 43450031
ReactomeREACT_23772
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| subClassOf | |
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| has input | |
| has output |
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