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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 | |
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| Definitions |
Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 The alpha subunit of the IL5 receptor binds IL-5 with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex may bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008). Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007473 |
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| comment |
Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 The alpha subunit of the IL5 receptor binds IL-5 with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex may bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008). Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06
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| definition source |
Pubmed2065657 Pubmed1833065 Reactome, http://www.reactome.org Pubmed18692472
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Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
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| prefixIRI |
HINO:0007473
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| prefLabel |
Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
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| seeAlso |
Reactome Database ID Release 43913370 ReactomeREACT_23992
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