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Human Interaction Network Ontology
| Preferred Name | Interleukin-5 receptor alpha subunit binds Interleukin-5 | |
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| Definitions |
Authored: Ray, KP, 2010-05-17 The Interleukin-5 receptor alpha subunit (IL5Ra) has a single transmembrane domain, a glycosylated extracellular domain and a short (58 amino acids) cytoplasmic tail, containing no tyrosine kinase domain. It binds IL-5 with a relatively low affinity and is not capable of signaling by itself. The alpha subunit has alternatively spliced soluble forms that are capable of binding IL-5 and act as natural antagonists of IL-5 signaling. The cytoplasmic domain of the alpha chain appears to be critical for IL-5 signaling (Takaki et al. 1993). IL5R alpha chain was found to be constitutively associated with JAK2 (Ogata et al. 1998); the same study found that JAK1 was constitutively associated with Bc, though the consensus is that JAK2 is associated with Bc. Edited: Jupe, S, 2010-08-06 Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06 |
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http://purl.obolibrary.org/obo/HINO_0007471 |
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| comment |
Authored: Ray, KP, 2010-05-17 The Interleukin-5 receptor alpha subunit (IL5Ra) has a single transmembrane domain, a glycosylated extracellular domain and a short (58 amino acids) cytoplasmic tail, containing no tyrosine kinase domain. It binds IL-5 with a relatively low affinity and is not capable of signaling by itself.
The alpha subunit has alternatively spliced soluble forms that are capable of binding IL-5 and act as natural antagonists of IL-5 signaling. The cytoplasmic domain of the alpha chain appears to be critical for IL-5 signaling (Takaki et al. 1993). IL5R alpha chain was found to be constitutively associated with JAK2 (Ogata et al. 1998); the same study found that JAK1 was constitutively associated with Bc, though the consensus is that JAK2 is associated with Bc. Edited: Jupe, S, 2010-08-06 Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06
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| definition source |
Pubmed9516124 Pubmed1833065 Reactome, http://www.reactome.org Pubmed8496674
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| label |
Interleukin-5 receptor alpha subunit binds Interleukin-5
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| prefixIRI |
HINO:0007471
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| prefLabel |
Interleukin-5 receptor alpha subunit binds Interleukin-5
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ReactomeREACT_23969 Reactome Database ID Release 43913456
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