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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0007444
http://purl.obolibrary.org/obo/HINO_0007444
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|---|---|
| Preferred Name | GM-CSF receptor alpha:GM-CSF binds Bc |
| Definitions |
Authored: Ray, KP, 2010-05-17
Edited: Jupe, S, 2010-08-06
The alpha subunit of the GM-CSF receptor binds GM-CSF with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of GM-CSF with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008).
Reviewed: Lopez, AF, 2010-09-06
Reviewed: Hercus, TR, 2010-09-06
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
GM-CSF receptor alpha:GM-CSF binds Bc
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| comment |
Authored: Ray, KP, 2010-05-17
Edited: Jupe, S, 2010-08-06
The alpha subunit of the GM-CSF receptor binds GM-CSF with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of GM-CSF with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008).
Reviewed: Lopez, AF, 2010-09-06
Reviewed: Hercus, TR, 2010-09-06
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| prefLabel |
GM-CSF receptor alpha:GM-CSF binds Bc
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| definition source |
Pubmed1833064
Pubmed19436055
Reactome, http://www.reactome.org
Pubmed18692472
Pubmed1702217
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| prefixIRI |
HINO:0007444
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| seeAlso |
Reactome Database ID Release 43913371
ReactomeREACT_23875
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| subClassOf | |
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| has output |
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