loading...| Preferred Name | GM-CSF receptor alpha subunit binds GM-CSF | |
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| Definitions |
The GM-CSF receptor alpha subunit has a single transmembrane domain, a glycosylated extracellular domain and a short (54 amino acids) cytoplasmic tail, containing no tyrosine kinase domain (Gearing et al. 1989). It binds GM-CSF with a relatively low affinity, and is not capable of signaling. The cytoplasmic domain of the alpha chain appears to be critical for GM-CSF signaling (Matsuguchi et al. 1997). Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007436 |
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| comment |
The GM-CSF receptor alpha subunit has a single transmembrane domain, a glycosylated extracellular domain and a short (54 amino acids) cytoplasmic tail, containing no tyrosine kinase domain (Gearing et al. 1989). It binds GM-CSF with a relatively low affinity, and is not capable of signaling. The cytoplasmic domain of the alpha chain appears to be critical for GM-CSF signaling (Matsuguchi et al. 1997). Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06 |
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| definition source |
Pubmed2555171 Reactome, http://www.reactome.org Pubmed9211889 |
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| label |
GM-CSF receptor alpha subunit binds GM-CSF |
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| prefixIRI |
HINO:0007436 |
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| prefLabel |
GM-CSF receptor alpha subunit binds GM-CSF |
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| seeAlso |
Reactome Database ID Release 43913360 ReactomeREACT_23919 |
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