Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Pyk2 is activated following IL2 stimulation
Synonyms
Definitions

Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 The proline rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko, 2005). PYK2 tyrosine phosphorlation is known to occur downstream of IL-2 stimulation in human peripheral T lymphocytes. This phosphorylation can be prevented by blocking IL-2 mediated JAK activity. Although the function of Pyk2 within the IL-2 signaling pathways remains uncertain, a dominant negative mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation which suggests that Pyk2 does indeed influence IL-2 driven immune cell responses.

ID

http://purl.obolibrary.org/obo/HINO_0007426

comment

Reviewed: Dooms, H, 2011-03-17

Reviewed: Villarino, A, 2011-02-11

Authored: Ray, KP, 2010-05-17

Edited: Jupe, S, 2010-08-06

The proline rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko, 2005). PYK2 tyrosine phosphorlation is known to occur downstream of IL-2 stimulation in human peripheral T lymphocytes. This phosphorylation can be prevented by blocking IL-2 mediated JAK activity. Although the function of Pyk2 within the IL-2 signaling pathways remains uncertain, a dominant negative mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation which suggests that Pyk2 does indeed influence IL-2 driven immune cell responses.

definition source

Pubmed9512511

Reactome, http://www.reactome.org

Pubmed15888917

Pubmed19207108

has input

http://purl.obolibrary.org/obo/HINO_0026341

has output

http://purl.obolibrary.org/obo/HINO_0026342

label

Pyk2 is activated following IL2 stimulation

prefixIRI

HINO:0007426

prefLabel

Pyk2 is activated following IL2 stimulation

seeAlso

ReactomeREACT_27136

Reactome Database ID Release 43508451

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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