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Human Interaction Network Ontology
Preferred Name | Pyk2 is activated following IL2 stimulation | |
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Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 The proline rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko, 2005). PYK2 tyrosine phosphorlation is known to occur downstream of IL-2 stimulation in human peripheral T lymphocytes. This phosphorylation can be prevented by blocking IL-2 mediated JAK activity. Although the function of Pyk2 within the IL-2 signaling pathways remains uncertain, a dominant negative mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation which suggests that Pyk2 does indeed influence IL-2 driven immune cell responses. |
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http://purl.obolibrary.org/obo/HINO_0007426 |
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Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 The proline rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko, 2005). PYK2 tyrosine phosphorlation is known to occur downstream of IL-2 stimulation in human peripheral T lymphocytes. This phosphorylation can be prevented by blocking IL-2 mediated JAK activity. Although the function of Pyk2 within the IL-2 signaling pathways remains uncertain, a dominant negative mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation which suggests that Pyk2 does indeed influence IL-2 driven immune cell responses.
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definition source |
Pubmed9512511 Reactome, http://www.reactome.org Pubmed15888917 Pubmed19207108
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Pyk2 is activated following IL2 stimulation
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prefixIRI |
HINO:0007426
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prefLabel |
Pyk2 is activated following IL2 stimulation
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seeAlso |
ReactomeREACT_27136 Reactome Database ID Release 43508451
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subClassOf |
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