loading...| Preferred Name | TRAF6 binding leads to IRAK1:TRAF6 release | |
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| Definitions |
MyD88 and Tollip only bind to non-phosphorylated IRAK1 [Wesche et al. 1997) so hyper-phosphorylated IRAK1 is predisposed to release from the receptor complex, a key step in this signaling cascade. It is believed that the interaction of IRAK1 with TRAF6 enables the release of IRAK1:TRAF6 from the receptor (Gottipati et al. 2007). Though released from the receptor complex, IRAK1:TRAF6 remains associated with the membrane, perhaps due to subsequent interaction with the TAK1 complex (Dong et al. 2006). Authored: Ray, KP, 2010-05-17 Reviewed: Pinteaux, E, 2010-05-17 Edited: Jupe, S, 2010-05-17 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007288 |
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| comment |
MyD88 and Tollip only bind to non-phosphorylated IRAK1 [Wesche et al. 1997) so hyper-phosphorylated IRAK1 is predisposed to release from the receptor complex, a key step in this signaling cascade. It is believed that the interaction of IRAK1 with TRAF6 enables the release of IRAK1:TRAF6 from the receptor (Gottipati et al. 2007). Though released from the receptor complex, IRAK1:TRAF6 remains associated with the membrane, perhaps due to subsequent interaction with the TAK1 complex (Dong et al. 2006). Authored: Ray, KP, 2010-05-17 Reviewed: Pinteaux, E, 2010-05-17 Edited: Jupe, S, 2010-05-17 |
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| definition source |
Pubmed16831874 Pubmed17890055 Reactome, http://www.reactome.org Pubmed9430229 |
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http://purl.obolibrary.org/obo/UniProt_Q9H0E2 http://purl.obolibrary.org/obo/HINO_0027463 |
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TRAF6 binding leads to IRAK1:TRAF6 release |
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| prefixIRI |
HINO:0007288 |
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| prefLabel |
TRAF6 binding leads to IRAK1:TRAF6 release |
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| seeAlso |
ReactomeREACT_22209 Reactome Database ID Release 43446894 |
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