loading...| Preferred Name | IRAK1 and 4 can phosphorylate Pellino-1 and 2. | |
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Authored: Ray, KP, 2010-05-17 IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably -3. Phosphorylation enhances the E3 ligase activity of Pellino-1 in conjunction with several different E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b). Phosphorylation at any of several different sites or a combination of other sites leads to full activation of Pellino-1 E3 ubiquitin ligase activity.<br><br>Though not shown here, the current models of IRAK1 involvement suggest it is part of a complex that includes TRAF6. Reviewed: Pinteaux, E, 2010-05-17 Edited: Jupe, S, 2010-05-17 |
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http://purl.obolibrary.org/obo/HINO_0007285 |
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Authored: Ray, KP, 2010-05-17 IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably -3. Phosphorylation enhances the E3 ligase activity of Pellino-1 in conjunction with several different E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b). Phosphorylation at any of several different sites or a combination of other sites leads to full activation of Pellino-1 E3 ubiquitin ligase activity. Reviewed: Pinteaux, E, 2010-05-17 Edited: Jupe, S, 2010-05-17 |
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| definition source |
Pubmed19264966 Pubmed12860405 Reactome, http://www.reactome.org |
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IRAK1 and 4 can phosphorylate Pellino-1 and 2. |
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HINO:0007285 |
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IRAK1 and 4 can phosphorylate Pellino-1 and 2. |
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Reactome Database ID Release 43450827 ReactomeREACT_22325 EC Number: 2.7.11 |
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