loading...| Preferred Name | NEMO binds polyubiquitinated IRAK1 | |
| Synonyms |
|
|
| Definitions |
NF-kappa-B essential modulator (NEMO, also known as IKKG abbreviated from Inhibitor of nuclear factor kappa-B kinase subunit gamma) is the regulatory subunit of the IKK complex which phosphorylates inhibitors of NF-kappa-B leading to dissociation of the inhibitor/NF-kappa-B complex. NEMO binds to K63-pUb chains (Ea et al. 2006; Wu et al. 2006), linking K63-pUb-hp-IRAK1 with the IKK complex. Models of IL-1R dependent activation of NF-kappaB suggest that the polyubiquitination of both TRAF6 and IRAK1 within a TRAF6:IRAK1 complex and their subsequent interactions with the TAK1 complex and IKK complex respectively brings these complexes into proximity, facilitating the TAK1-catalyzed activation of IKK (Moynagh, 2008). Authored: Ray, KP, 2010-05-17 Reviewed: Pinteaux, E, 2010-05-17 Edited: Jupe, S, 2010-05-17 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0007282 |
|
| comment |
NF-kappa-B essential modulator (NEMO, also known as IKKG abbreviated from Inhibitor of nuclear factor kappa-B kinase subunit gamma) is the regulatory subunit of the IKK complex which phosphorylates inhibitors of NF-kappa-B leading to dissociation of the inhibitor/NF-kappa-B complex. NEMO binds to K63-pUb chains (Ea et al. 2006; Wu et al. 2006), linking K63-pUb-hp-IRAK1 with the IKK complex. Models of IL-1R dependent activation of NF-kappaB suggest that the polyubiquitination of both TRAF6 and IRAK1 within a TRAF6:IRAK1 complex and their subsequent interactions with the TAK1 complex and IKK complex respectively brings these complexes into proximity, facilitating the TAK1-catalyzed activation of IKK (Moynagh, 2008). Authored: Ray, KP, 2010-05-17 Reviewed: Pinteaux, E, 2010-05-17 Edited: Jupe, S, 2010-05-17 |
|
| definition source |
Pubmed16603398 Reactome, http://www.reactome.org Pubmed19022706 Pubmed18180283 Pubmed16547522 |
|
| has input | ||
| has output | ||
| label |
NEMO binds polyubiquitinated IRAK1 |
|
| prefixIRI |
HINO:0007282 |
|
| prefLabel |
NEMO binds polyubiquitinated IRAK1 |
|
| seeAlso |
Reactome Database ID Release 43451561 ReactomeREACT_22256 |
|
| subClassOf |