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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0007278
http://purl.obolibrary.org/obo/HINO_0007278
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| Preferred Name | Polyubiquitinated TRAF6 interacts with TAK1 complex |
| Definitions |
Authored: Ray, KP, 2010-05-17
Reviewed: Pinteaux, E, 2010-05-17
TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a complex that also contains TAK1 and TAB1, binds polyubiquitinated TRAF6. The TAB2 and TAB3 regulatory subunits of the TAK1 complex contain C-terminal Npl4 zinc finger (NZF) motifs that recognize with Lys63-pUb chains (Kanayama et al. 2004). The recognition mechanism is specific for Lys63-linked ubiquitin chains [Kulathu Y et al 2009]. TAK1 can be activated by unattached Lys63-polyubiquitinated chains when TRAF6 has no detectable polyubiquitination (Xia et al. 2009) and thus the synthesis of these chains by TRAF6 may be the signal transduction mechanism.
Edited: Jupe, S, 2010-05-17
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Polyubiquitinated TRAF6 interacts with TAK1 complex
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| comment |
Authored: Ray, KP, 2010-05-17
Reviewed: Pinteaux, E, 2010-05-17
TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a complex that also contains TAK1 and TAB1, binds polyubiquitinated TRAF6. The TAB2 and TAB3 regulatory subunits of the TAK1 complex contain C-terminal Npl4 zinc finger (NZF) motifs that recognize with Lys63-pUb chains (Kanayama et al. 2004). The recognition mechanism is specific for Lys63-linked ubiquitin chains [Kulathu Y et al 2009]. TAK1 can be activated by unattached Lys63-polyubiquitinated chains when TRAF6 has no detectable polyubiquitination (Xia et al. 2009) and thus the synthesis of these chains by TRAF6 may be the signal transduction mechanism.
Edited: Jupe, S, 2010-05-17
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| prefLabel |
Polyubiquitinated TRAF6 interacts with TAK1 complex
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| definition source |
Pubmed19675569
Reactome, http://www.reactome.org
Pubmed10882101
Pubmed15327770
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| prefixIRI |
HINO:0007278
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| seeAlso |
ReactomeREACT_22322
Reactome Database ID Release 43446870
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| has output |
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