loading...| Preferred Name | Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 | |
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| Definitions |
Ubiquitin specific protease 18 (USP18/UBP43) is the major ISG15 deconjugating enzyme. It removes ISG15 from ISGylated proteins. ISG15-specific protease activity of this enzyme is crucial for proper cellular balance of ISG15-conjugated proteins. However, it is not required for processing pre-ISG15 to the mature form. Furthermore, USP18 inhibits type I interferon signaling independent of its ISG15 deconjugating enzyme activity. Several viral proteins were also reported with de-ISGylation activity. Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- Edited: Garapati, P V, 2011-01-18 |
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http://purl.obolibrary.org/obo/HINO_0007235 |
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Ubiquitin specific protease 18 (USP18/UBP43) is the major ISG15 deconjugating enzyme. It removes ISG15 from ISGylated proteins. ISG15-specific protease activity of this enzyme is crucial for proper cellular balance of ISG15-conjugated proteins. However, it is not required for processing pre-ISG15 to the mature form. Furthermore, USP18 inhibits type I interferon signaling independent of its ISG15 deconjugating enzyme activity. Several viral proteins were also reported with de-ISGylation activity. Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- Edited: Garapati, P V, 2011-01-18 |
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| definition source |
Pubmed17692280 Reactome, http://www.reactome.org Pubmed16710296 Pubmed11788588 Pubmed20181693 |
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Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 |
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HINO:0007235 |
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Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 |
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ReactomeREACT_115684 Reactome Database ID Release 431678841 |
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