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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | ISGylation of IRF3 | |
| Synonyms |
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| Definitions |
Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation. Edited: Garapati, P V, 2011-01-18 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007157 |
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| comment |
Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation. Edited: Garapati, P V, 2011-01-18
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| definition source |
Pubmed20308324 Reactome, http://www.reactome.org Pubmed16914094 Pubmed20153823
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| has input |
http://purl.obolibrary.org/obo/HINO_0027421 |
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| has output |
http://purl.obolibrary.org/obo/CHEBI_29888 http://purl.obolibrary.org/obo/HINO_0007551 http://purl.obolibrary.org/obo/UniProt_O14933 |
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| label |
ISGylation of IRF3
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| prefixIRI |
HINO:0007157
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| prefLabel |
ISGylation of IRF3
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| seeAlso |
Reactome Database ID Release 431169394 EC Number: 6.3.2.19 ReactomeREACT_115934
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