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Human Interaction Network Ontology
| Preferred Name | ISGylation of viral protein NS1 | |
| Synonyms |
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| Definitions |
Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- Edited: Garapati, P V, 2011-01-18 Some viral proteins are also targeted for ISGylation. The well studied viral protein ISGylation is the modification of the influenza A viral protein NS1, which functions as an IFN antagonist during viral infection. Studies identified seven lysine residues in NS1 as potential ISGylation sites among which K41 (Zhao et al. 2010), K126 and K217 (Tang et al. 2010) were found to be critical. ISGylation at these sites disrupts NS1 association with importin-alpha, a protein required for the nuclear import of NS1. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007155 |
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| comment |
Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- Edited: Garapati, P V, 2011-01-18 Some viral proteins are also targeted for ISGylation. The well studied viral protein ISGylation is the modification of the influenza A viral protein NS1, which functions as an IFN antagonist during viral infection. Studies identified seven lysine residues in NS1 as potential ISGylation sites among which K41 (Zhao et al. 2010), K126 and K217 (Tang et al. 2010) were found to be critical. ISGylation at these sites disrupts NS1 association with importin-alpha, a protein required for the nuclear import of NS1.
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| definition source |
Reactome, http://www.reactome.org Pubmed20133869 Pubmed20385878 Pubmed20219937
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| has input |
http://purl.obolibrary.org/obo/UniProt_P03496 |
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| has output |
http://purl.obolibrary.org/obo/CHEBI_29888 http://purl.obolibrary.org/obo/HINO_0007551 http://purl.obolibrary.org/obo/HINO_0027429 |
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| label |
ISGylation of viral protein NS1
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| prefixIRI |
HINO:0007155
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| prefLabel |
ISGylation of viral protein NS1
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| seeAlso |
EC Number: 6.3.2.19 ReactomeREACT_115965 Reactome Database ID Release 431169395
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