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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | ISGylation of E2 conjugating enzymes | |
| Synonyms |
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| Definitions |
Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005). Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- Edited: Garapati, P V, 2011-01-18 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007152 |
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| comment |
Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005). Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- Edited: Garapati, P V, 2011-01-18
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| definition source |
Reactome, http://www.reactome.org Pubmed16428300 Pubmed20153823 Pubmed16122702 Pubmed16112642
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| has input |
http://purl.obolibrary.org/obo/HINO_0027421 |
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| has output |
http://purl.obolibrary.org/obo/CHEBI_29888 http://purl.obolibrary.org/obo/HINO_0007551 http://purl.obolibrary.org/obo/UniProt_O14933 |
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| label |
ISGylation of E2 conjugating enzymes
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| prefixIRI |
HINO:0007152
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| prefLabel |
ISGylation of E2 conjugating enzymes
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| seeAlso |
ReactomeREACT_115543 EC Number: 6.3.2.19 Reactome Database ID Release 431169402
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