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Human Interaction Network Ontology
| Preferred Name | ISGylation of host protein filamin B | |
| Synonyms |
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| Definitions |
ISG15 negatively regulates the scaffold protein filamin B. In response to type I IFNs, filamin B recruits RAC1, MEKK1, and MKK4, enhancing their sequential activation and thereby promoting JNK activation and apoptosis. ISGylation of filamin B leads to the disassociation of RAC1, MEKK1, and MKK4 from the scaffold, preventing type I IFN dependent JNK activation and apoptosis. It has been suggested that this inhibition of apoptosis may protect uninfected bystander cells from IFN-mediated apoptosis (Jeon et al, 2009). Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- Edited: Garapati, P V, 2011-01-18 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0007150 |
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| comment |
ISG15 negatively regulates the scaffold protein filamin B. In response to type I IFNs, filamin B recruits RAC1, MEKK1, and MKK4, enhancing their sequential activation and thereby promoting JNK activation and apoptosis. ISGylation of filamin B leads to the disassociation of RAC1, MEKK1, and MKK4 from the scaffold, preventing type I IFN dependent JNK activation and apoptosis. It has been suggested that this inhibition of apoptosis may protect uninfected bystander cells from IFN-mediated apoptosis (Jeon et al, 2009). Authored: Garapati, P V, 2011-01-18 Reviewed: Zhang, DE, 2011--0-2- Edited: Garapati, P V, 2011-01-18
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| definition source |
Pubmed19270716 Reactome, http://www.reactome.org Pubmed16009940 Pubmed12582176 Pubmed20153823 Pubmed20946978
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| has input |
http://purl.obolibrary.org/obo/HINO_0027421 |
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| has output |
http://purl.obolibrary.org/obo/CHEBI_29888 http://purl.obolibrary.org/obo/HINO_0007551 http://purl.obolibrary.org/obo/UniProt_O14933 |
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| label |
ISGylation of host protein filamin B
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| prefixIRI |
HINO:0007150
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| prefLabel |
ISGylation of host protein filamin B
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| seeAlso |
ReactomeREACT_115658 EC Number: 6.3.2.19 Reactome Database ID Release 431169398
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