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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0007006
http://purl.obolibrary.org/obo/HINO_0007006
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|---|---|
| Preferred Name | Phosphorylated SHC recruits GRB2:SOS1 |
| Definitions |
Reviewed: Dooms, H, 2011-03-17
Reviewed: Villarino, A, 2011-02-11
has a Stoichiometric coefficient of 4
Authored: Ray, KP, 2010-05-17
Shc is tyrosine phosphorylated by an unidentified kinase, creating a docking site for the SH2 domain of Grb2 (Zhu et al. 1994). Grb2 is an adaptor protein believed to be constitutively associated with the guanine nucleotide exchange protein Sos1 (often abbreviated to Sos). Recruitment of the Grb2:Sos1 complex leads to activation of the Ras pathway (Ravichandran & Burakoff 1994) and consequently activation of the MAPK pathway.
Edited: Jupe, S, 2010-08-06
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Phosphorylated SHC recruits GRB2:SOS1
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| comment |
Reviewed: Dooms, H, 2011-03-17
Reviewed: Villarino, A, 2011-02-11
has a Stoichiometric coefficient of 4
Authored: Ray, KP, 2010-05-17
Shc is tyrosine phosphorylated by an unidentified kinase, creating a docking site for the SH2 domain of Grb2 (Zhu et al. 1994). Grb2 is an adaptor protein believed to be constitutively associated with the guanine nucleotide exchange protein Sos1 (often abbreviated to Sos). Recruitment of the Grb2:Sos1 complex leads to activation of the Ras pathway (Ravichandran & Burakoff 1994) and consequently activation of the MAPK pathway.
Edited: Jupe, S, 2010-08-06
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| prefLabel |
Phosphorylated SHC recruits GRB2:SOS1
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| definition source |
Pubmed8119884
Reactome, http://www.reactome.org
Pubmed1465135
Pubmed8294403
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| prefixIRI |
HINO:0007006
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| seeAlso |
ReactomeREACT_23828
Reactome Database ID Release 43453111
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| subClassOf | |
| type | |
| has input | |
| has output |
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