loading...| Preferred Name | SOS1 activates H-Ras | |
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| Definitions |
Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Recruitment of Sos1 to the receptor complex brings it into contact with membrane-associated Ras-GDP. Interactions with Ras modulate Sos1 activity in a two-step manner (McKay & Morrison, 2007). Sos1 acts as a guanine exchange factor for Ras (Chardin et al. 1993), activating the Ras-Raf-MAPK pathway. |
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http://purl.obolibrary.org/obo/HINO_0006994 |
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| comment |
Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Recruitment of Sos1 to the receptor complex brings it into contact with membrane-associated Ras-GDP. Interactions with Ras modulate Sos1 activity in a two-step manner (McKay & Morrison, 2007). Sos1 acts as a guanine exchange factor for Ras (Chardin et al. 1993), activating the Ras-Raf-MAPK pathway. |
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| definition source |
Pubmed17496910 Pubmed8493579 Reactome, http://www.reactome.org |
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| label |
SOS1 activates H-Ras |
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| prefixIRI |
HINO:0006994 |
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| prefLabel |
SOS1 activates H-Ras |
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| seeAlso |
ReactomeREACT_23928 Reactome Database ID Release 43508236 |
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