loading...| Preferred Name |
LTB4 is hydroxylated to 20oh-LTB4 by CYP4F2/4F3 |
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| Definitions |
Reviewed: Rush, MG, 2012-11-10 Edited: Jassal, B, 2008-05-19 12:57:01 Authored: Jassal, B, 2008-05-19 12:57:01 Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998). |
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http://purl.obolibrary.org/obo/HINO_0006510 |
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| comment |
Reviewed: Rush, MG, 2012-11-10 Edited: Jassal, B, 2008-05-19 12:57:01 Authored: Jassal, B, 2008-05-19 12:57:01 Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998). |
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| definition source |
Reactome, http://www.reactome.org Pubmed9539102 Pubmed9799565 |
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| has input |
http://purl.obolibrary.org/obo/CHEBI_16474 http://purl.obolibrary.org/obo/CHEBI_15379 |
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| has output |
http://purl.obolibrary.org/obo/CHEBI_15646 |
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| label |
LTB4 is hydroxylated to 20oh-LTB4 by CYP4F2/4F3 |
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| name |
CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it |
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| prefixIRI |
HINO:0006510 |
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| prefLabel |
LTB4 is hydroxylated to 20oh-LTB4 by CYP4F2/4F3 |
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| seeAlso |
ReactomeREACT_13738 EC Number: 1.14.13.30 Reactome Database ID Release 43211873 |
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