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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0006483
http://purl.obolibrary.org/obo/HINO_0006483
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|---|---|
| Preferred Name | Tyrosine phosphorylation of STATs by IL6 receptor |
| Definitions |
has a Stoichiometric coefficient of 2
Authored: Ray, K, 2010-12-13
IL-6 activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT1 this is tyrosine-701, for STAT3 tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the dimers bind to enhancers of interleukin-6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation.
Edited: Jupe, S, 2010-12-10
Reviewed: Rose-John, S, 2011-02-11
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Tyrosine phosphorylation of STATs by IL6 receptor
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|---|---|
| comment |
has a Stoichiometric coefficient of 2
Authored: Ray, K, 2010-12-13
IL-6 activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT1 this is tyrosine-701, for STAT3 tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the dimers bind to enhancers of interleukin-6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation.
Edited: Jupe, S, 2010-12-10
Reviewed: Rose-John, S, 2011-02-11
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| prefLabel |
Tyrosine phosphorylation of STATs by IL6 receptor
|
| definition source |
Pubmed8626374
Pubmed8662795
Pubmed7510216
Reactome, http://www.reactome.org
Pubmed8140422
Pubmed7512451
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| prefixIRI |
HINO:0006483
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| seeAlso |
Reactome Database ID Release 431112602
EC Number: 2.7.10.2
ReactomeREACT_27203
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| subClassOf | |
| type | |
| has input | |
| has output |
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