loading...| Preferred Name | Interleukin-6 binds to soluble IL-6 receptor | |
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| Definitions |
The short, soluble form of Interleukin-6 receptor alpha (sIL6R), like the longer membrane-associated form IL6RA, binds circulating Interleukin-6 (IL-6). sIL6R is generated by limited proteolysis of the longer membrane associated form and by translation of an alternatively spliced mRNA. The IL-6:sIL6R dimer can associate with the IL6 receptor signaling beta subunit gp130 and stimulate cells that do not express IL6RA, a process termed trans-signaling. Gp130 is widely expressed in many cell types that do not express IL6RA (Rose-John et al. 2006). Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 Reviewed: Rose-John, S, 2011-02-11 |
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http://purl.obolibrary.org/obo/HINO_0006462 |
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The short, soluble form of Interleukin-6 receptor alpha (sIL6R), like the longer membrane-associated form IL6RA, binds circulating Interleukin-6 (IL-6). sIL6R is generated by limited proteolysis of the longer membrane associated form and by translation of an alternatively spliced mRNA. The IL-6:sIL6R dimer can associate with the IL6 receptor signaling beta subunit gp130 and stimulate cells that do not express IL6RA, a process termed trans-signaling. Gp130 is widely expressed in many cell types that do not express IL6RA (Rose-John et al. 2006). Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 Reviewed: Rose-John, S, 2011-02-11 |
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| definition source |
Reactome, http://www.reactome.org Pubmed16707558 Pubmed2788034 |
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Interleukin-6 binds to soluble IL-6 receptor |
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HINO:0006462 |
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Interleukin-6 binds to soluble IL-6 receptor |
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| seeAlso |
Reactome Database ID Release 431067640 ReactomeREACT_27133 |
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