loading...| Preferred Name | IL6:sIL6R binds sgp130 | |
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| Definitions |
Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 Soluble gp130 binds to circulating IL6:sIL6R, preventing binding to gp130 on the plasma membrane, thereby specifically inhibiting IL-6 trans-signaling (Jostock et al. 2001). This protein is to enter clinical development for the treatment of inflammatory diseases. It can be anticipated that less beneficial activities of IL-6 will be blocked by soluble gp130 than by global blockade of IL-6 with neutralizing monoclonal antibodies to IL-6 or IL-6R Reviewed: Rose-John, S, 2011-02-11 |
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http://purl.obolibrary.org/obo/HINO_0006461 |
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| comment |
Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 Soluble gp130 binds to circulating IL6:sIL6R, preventing binding to gp130 on the plasma membrane, thereby specifically inhibiting IL-6 trans-signaling (Jostock et al. 2001). This protein is to enter clinical development for the treatment of inflammatory diseases. It can be anticipated that less beneficial activities of IL-6 will be blocked by soluble gp130 than by global blockade of IL-6 with neutralizing monoclonal antibodies to IL-6 or IL-6R Reviewed: Rose-John, S, 2011-02-11 |
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| definition source |
Reactome, http://www.reactome.org Pubmed11121117 |
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| label |
IL6:sIL6R binds sgp130 |
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| prefixIRI |
HINO:0006461 |
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| prefLabel |
IL6:sIL6R binds sgp130 |
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| seeAlso |
Reactome Database ID Release 431067676 ReactomeREACT_27205 |
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