loading...| Preferred Name | CBL binds B-cell linker protein | |
| Synonyms |
|
|
| Definitions |
Cbl binds B-cell linker protein, a molecular scaffold bridging Syk to downstream signaling pathways by recruiting signaling molecules, such as Btk, phospholipase C gamma 2, Vav, and Grb2 to the cell membrane to form a signalosome complex. Cbl is believed to negatively regulate signaling from this complex. Consistent with this, Cbl inactivation reverses a number of critical defects in early B cell differentiation seen in BLNK-deficient mice (Song et al. 2007). Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0006419 |
|
| comment |
Cbl binds B-cell linker protein, a molecular scaffold bridging Syk to downstream signaling pathways by recruiting signaling molecules, such as Btk, phospholipase C gamma 2, Vav, and Grb2 to the cell membrane to form a signalosome complex. Cbl is believed to negatively regulate signaling from this complex. Consistent with this, Cbl inactivation reverses a number of critical defects in early B cell differentiation seen in BLNK-deficient mice (Song et al. 2007). Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06 |
|
| definition source |
Pubmed17202354 Reactome, http://www.reactome.org |
|
| has input | ||
| has output | ||
| label |
CBL binds B-cell linker protein |
|
| prefixIRI |
HINO:0006419 |
|
| prefLabel |
CBL binds B-cell linker protein |
|
| seeAlso |
ReactomeREACT_23998 Reactome Database ID Release 43912724 |
|
| subClassOf |