Authored: Ray, KP, 2010-05-17 IL3 stimulation induces rapid and transient tyrosine-phosphorylation of Vav and the binding of Vav to Tec kinase through Tec homology domains. (Machide et al. 1995). Vav1 and Tec were seen to associate into a complex with the activated prolactin receptor (Kline et al. 2001). These reports were interpreted as Tec enhancing Vav GEF activity, but it has been suggested that Vav might contribute to Tec activation in T cell signaling (Reynolds et al. 2002). Tec kinases generally require PI3K-dependent membrane translocation and phosphorylation of the kinase domain, often by an Src family kinase, for activation (Takesono et al. 2002). Edited: Jupe, S, 2010-08-06 Reviewed: Lopez, AF, 2010-09-06 Reviewed: Hercus, TR, 2010-09-06

http://purl.obolibrary.org/obo/HINO_0006417

Authored: Ray, KP, 2010-05-17

IL3 stimulation induces rapid and transient tyrosine-phosphorylation of Vav and the binding of Vav to Tec kinase through Tec homology domains. (Machide et al. 1995). Vav1 and Tec were seen to associate into a complex with the activated prolactin receptor (Kline et al. 2001). These reports were interpreted as Tec enhancing Vav GEF activity, but it has been suggested that Vav might contribute to Tec activation in T cell signaling (Reynolds et al. 2002). Tec kinases generally require PI3K-dependent membrane translocation and phosphorylation of the kinase domain, often by an Src family kinase, for activation (Takesono et al. 2002).

Edited: Jupe, S, 2010-08-06

Reviewed: Lopez, AF, 2010-09-06

Reviewed: Hercus, TR, 2010-09-06

Pubmed12118060

Reactome, http://www.reactome.org

Pubmed11328862

Pubmed11994416

Pubmed7651724

http://purl.obolibrary.org/obo/UniProt_P15498

http://purl.obolibrary.org/obo/UniProt_P42680

http://purl.obolibrary.org/obo/HINO_0026408

IL3 stimulation induces Vav binding to Tec kinase

HINO:0006417

IL3 stimulation induces Vav binding to Tec kinase

Reactome Database ID Release 43879914

ReactomeREACT_23914

http://purl.obolibrary.org/obo/INO_0000040