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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0006401
http://purl.obolibrary.org/obo/HINO_0006401
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|---|---|
| Preferred Name | Growth hormone receptor binds JAK2 |
| Definitions |
Authored: Jupe, S, 2010-10-14
Reviewed: Waters, MJ, 2011-06-23
Edited: Jupe, S, 2011-06-10
JAKs bind to the box1 motif (residues 297-305) of the Growth Hormone Receptor (GHR) (Argetsinger et al. 1993), a proline-rich region just inside the cell membrane. Binding is mediated largely by the JAK N-terminal FERM domain (Frank et al. 1995, He et al. 2003). JAK 2 binding enhances the stability of GHR (He et al. 2005).
Reviewed: Herington, AC, 2011-06-13
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Growth hormone receptor binds JAK2
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| comment |
Authored: Jupe, S, 2010-10-14
Reviewed: Waters, MJ, 2011-06-23
Edited: Jupe, S, 2011-06-10
JAKs bind to the box1 motif (residues 297-305) of the Growth Hormone Receptor (GHR) (Argetsinger et al. 1993), a proline-rich region just inside the cell membrane. Binding is mediated largely by the JAK N-terminal FERM domain (Frank et al. 1995, He et al. 2003). JAK 2 binding enhances the stability of GHR (He et al. 2005).
Reviewed: Herington, AC, 2011-06-13
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| prefLabel |
Growth hormone receptor binds JAK2
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| definition source |
Pubmed16081639
Reactome, http://www.reactome.org
Pubmed8343952
Pubmed12920237
Pubmed7956946
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| prefixIRI |
HINO:0006401
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| seeAlso |
ReactomeREACT_111052
Reactome Database ID Release 43982792
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| subClassOf | |
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| has input | |
| has output |
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