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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Growth hormone receptor dimerizes | |
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| Definitions |
has a Stoichiometric coefficient of 2 The growth hormone receptor forms dimers (Cunningham et al. 1991) that subsequently signal via JAK2 (Argetsinger et al. 1993). Early studies suggested that dimerization occured following ligand binding, but it is now generally accepted that dimerization is independent of ligand binding and involves the transmembrane and juxtamembrane domains (van den Eijnden et al. 2006, Brown et al. 2005). Authored: Jupe, S, 2010-10-14 Reviewed: Waters, MJ, 2011-06-23 Edited: Jupe, S, 2011-06-10 Reviewed: Herington, AC, 2011-06-13 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0006400 |
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| comment |
has a Stoichiometric coefficient of 2 The growth hormone receptor forms dimers (Cunningham et al. 1991) that subsequently signal via JAK2 (Argetsinger et al. 1993). Early studies suggested that dimerization occured following ligand binding, but it is now generally accepted that dimerization is independent of ligand binding and involves the transmembrane and juxtamembrane domains (van den Eijnden et al. 2006, Brown et al. 2005). Authored: Jupe, S, 2010-10-14 Reviewed: Waters, MJ, 2011-06-23 Edited: Jupe, S, 2011-06-10 Reviewed: Herington, AC, 2011-06-13
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| definition source |
Pubmed1948064 Reactome, http://www.reactome.org Pubmed8343952 Pubmed16820415 Pubmed16116438
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| label |
Growth hormone receptor dimerizes
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| prefixIRI |
HINO:0006400
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| prefLabel |
Growth hormone receptor dimerizes
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| seeAlso |
Reactome Database ID Release 43982775 ReactomeREACT_111208
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