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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0006394
http://purl.obolibrary.org/obo/HINO_0006394
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|---|---|
| Preferred Name | Interleukin-7:IL7RA:JAK1 binds Gc:JAK3 |
| Definitions |
Authored: Ray, KP, 2010-05-17
Studies using chemical crosslinking and monoclonal antibodies specific for the IL-2 receptor gamma chain (Gc) demonstrated that Gc participates in the functional high-affinity interleukin-7 receptor complex (Noguchi et al. 1993, Kondo et al. 1994). <br><br>The membrane-associated Gc chain interacts with the intermediate 1:1 IL7:IL7R complex, forming the active ternary complex, which binds IL7 with a 3-fold higher affinity (Kd =80 pM).
Edited: Jupe, S, 2011-05-06
Reviewed: Puck, J, 2011-11-03
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Interleukin-7:IL7RA:JAK1 binds Gc:JAK3
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| comment |
Authored: Ray, KP, 2010-05-17
Studies using chemical crosslinking and monoclonal antibodies specific for the IL-2 receptor gamma chain (Gc) demonstrated that Gc participates in the functional high-affinity interleukin-7 receptor complex (Noguchi et al. 1993, Kondo et al. 1994). <br><br>The membrane-associated Gc chain interacts with the intermediate 1:1 IL7:IL7R complex, forming the active ternary complex, which binds IL7 with a 3-fold higher affinity (Kd =80 pM).
Edited: Jupe, S, 2011-05-06
Reviewed: Puck, J, 2011-11-03
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| prefLabel |
Interleukin-7:IL7RA:JAK1 binds Gc:JAK3
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| definition source |
Pubmed8128231
Reactome, http://www.reactome.org
Pubmed8266077
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| prefixIRI |
HINO:0006394
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| seeAlso |
Reactome Database ID Release 43449958
ReactomeREACT_115695
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| subClassOf | |
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| has output |
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